Sexual Transmitted Infections Archives

Retrospective and Comparative Study of Three Molecular Assays for the Macrolide Resistance Detection in Mycoplasma genitalium Positive Urogenital Specimens

The capacity of Mycoplasma genitalium to develop resistance to macrolides makes detection of macrolide resistance genes by rapid real-time PCR assays increasingly necessary in clinical diagnostic laboratories so as to initiate appropriate treatment as rapidly as possible. The aim of this retrospective and comparative study was to conduct the clinical evaluation of three commercially available kits for macrolide resistance detection.

Clinical Performance of Three Commercial Molecular Diagnostic Assays for the Detection of Fluoroquinolone Resistance-Associated Mutations in Mycoplasma genitalium

In the absence of Ser83Ile (G248T) and mutations at position at 83 and 87 in parC, the probability of moxifloxacin cure of macrolide-resistant Mycoplasma genitalium was 96.4% and 97.8%, respectively. This suggests that selection of antibiotics via testing the existence of parC mutation using Allplex™ MG & MoxiR Assay is essential in increasing the treatment efficiency of Mycoplasma genitalium.

Clinical validation of a new molecular test (Seegene Allplex™ Vaginitis) for the diagnosis of vaginitis: a cross-sectional study

The study demonstrated that Allplex™ Vaginitis Screening Assay’s convenience and excellence by comparing the reference method and performance by each target.

Low prevalence of macrolide resistance in Mycoplasma genitalium infections in a cohort of pregnant women living with human immunodeficiency virus

Macrolide resistance in Mycoplasma genitalium (M. genitalium) is increasing as a result of the widespread use of azithromycin in the treatment of sexually transmitted infections (STIs). To date, there are few published studies on macrolide resistance patterns in South African pregnant women. This study now contributes to the growing body of knowledge.

Performance of two commercial multiplex polymerase chain reaction assays for the etiological diagnosis of sexually transmitted infections among men who have sex with men

This paper supports the performance of Allplex™ STI Essential Assay as syndromic testing. Allplex™ STI Essential Assay can detect pathogens as MG, MH, and UU, and there were single infections of these pathogens among the study population.